APC mutations in human colon lead to decreased neuroendocrine maturation of ALDH+ stem cells that alters GLP-2 and SST feedback signaling: Clue to a link between WNT and retinoic acid signalling in colon cancer development

APC mutations drive human colorectal cancer (CRC) development. A major contributing factor is colonic stem cell (SC) overpopulation. But, the mechanism has not been fully identified. A possible mechanism is the dysregulation of neuroendocrine cell (NEC) maturation by APC mutations because SCs and NE...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Zhang, Tao, Ahn, Koree, Emerick, Brooks, Modarai, Shirin R., Opdenaker, Lynn M., Palazzo, Juan, Schleiniger, Gilberto, Fields, Jeremy Z., Boman, Bruce M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7592776/
https://ncbi.nlm.nih.gov/pubmed/33112876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0239601
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