Phosphatase activity of small C-terminal domain phosphatase 1 (SCP1) controls the stability of the key neuronal regulator RE1-silencing transcription factor (REST)

The RE1-silencing transcription factor (REST) is the major scaffold protein for assembly of neuronal gene silencing complexes that suppress gene transcription through regulating the surrounding chromatin structure. REST represses neuronal gene expression in stem cells and non-neuronal cells, but it...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Burkholder, Nathaniel Tate, Mayfield, Joshua E., Yu, Xiaohua, Irani, Seema, Arce, Daniel K., Jiang, Faqin, Matthews, Wendy L., Xue, Yuanchao, Zhang, Yan Jessie
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2018
Subjects:
Molecular Biophysics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6204920/
https://ncbi.nlm.nih.gov/pubmed/30217818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004722
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