Oral Immunization with Nontoxigenic Clostridium difficile Strains Expressing Chimeric Fragments of TcdA and TcdB Elicits Protective Immunity against C. difficile Infection in Both Mice and Hamsters

The symptoms of Clostridium difficile infection (CDI) are attributed largely to two C. difficile toxins, TcdA and TcdB. Significant efforts have been devoted to developing vaccines targeting both toxins through parenteral immunization routes. However, C. difficile is an enteric pathogen, and mucosal...

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Опубликовано в: :Infect Immun
Главные авторы: Wang, Yuanguo, Wang, Shaohui, Bouillaut, Laurent, Li, Chunhui, Duan, Zhibian, Zhang, Keshan, Ju, Xianghong, Tzipori, Saul, Sonenshein, Abraham L., Sun, Xingmin
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2018
Предметы:
Host Response and Inflammation
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6204701/
https://ncbi.nlm.nih.gov/pubmed/30150259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00489-18
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