Oral Immunization with Nontoxigenic Clostridium difficile Strains Expressing Chimeric Fragments of TcdA and TcdB Elicits Protective Immunity against C. difficile Infection in Both Mice and Hamsters

The symptoms of Clostridium difficile infection (CDI) are attributed largely to two C. difficile toxins, TcdA and TcdB. Significant efforts have been devoted to developing vaccines targeting both toxins through parenteral immunization routes. However, C. difficile is an enteric pathogen, and mucosal...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Infect Immun
Main Authors: Wang, Yuanguo, Wang, Shaohui, Bouillaut, Laurent, Li, Chunhui, Duan, Zhibian, Zhang, Keshan, Ju, Xianghong, Tzipori, Saul, Sonenshein, Abraham L., Sun, Xingmin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Host Response and Inflammation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6204701/
https://ncbi.nlm.nih.gov/pubmed/30150259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00489-18
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados