Oral Immunization with Nontoxigenic Clostridium difficile Strains Expressing Chimeric Fragments of TcdA and TcdB Elicits Protective Immunity against C. difficile Infection in Both Mice and Hamsters

The symptoms of Clostridium difficile infection (CDI) are attributed largely to two C. difficile toxins, TcdA and TcdB. Significant efforts have been devoted to developing vaccines targeting both toxins through parenteral immunization routes. However, C. difficile is an enteric pathogen, and mucosal...

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Bibliographic Details
Published in:Infect Immun
Main Authors: Wang, Yuanguo, Wang, Shaohui, Bouillaut, Laurent, Li, Chunhui, Duan, Zhibian, Zhang, Keshan, Ju, Xianghong, Tzipori, Saul, Sonenshein, Abraham L., Sun, Xingmin
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2018
Subjects:
Host Response and Inflammation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6204701/
https://ncbi.nlm.nih.gov/pubmed/30150259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00489-18
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