An RORγt Oral Inhibitor Modulates IL-17 Responses in Peripheral Blood and Intestinal Mucosa of Crohn's Disease Patients

Background and Aims: Despite the negative results of blocking IL-17 in Crohn's disease (CD) patients, selective modulation of Th17-dependent responses warrants further study. Inhibition of retinoic acid-related orphan receptor gamma (RORγt), the master regulator of the Th17 signature, is curren...

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Udgivet i:Front Immunol
Main Authors: Bassolas-Molina, Helena, Raymond, Ernest, Labadia, Mark, Wahle, Joseph, Ferrer-Picón, Elena, Panzenbeck, Mark, Zheng, Jie, Harcken, Christian, Hughes, Robert, Turner, Michael, Smith, Dustin, Calderón-Gómez, Elisabeth, Esteller, Míriam, Carrasco, Anna, Esteve, Maria, Dotti, Isabella, Corraliza, Ana Maria, Masamunt, Maria Carme, Arajol, Clàudia, Guardiola, Jordi, Ricart, Elena, Nabozny, Gerald, Salas, Azucena
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6204372/
https://ncbi.nlm.nih.gov/pubmed/30405600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02307
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