Phase 1 study of ARQ 761, a β-lapachone analogue that promotes NQO1-mediated programmed cancer cell necrosis

BACKGROUND: NAD(P)H:quinone oxidoreductase 1 (NQO1) is a two-electron oxidoreductase expressed in multiple tumour types. ARQ 761 is a β-lapachone (β-lap) analogue that exploits the unique elevation of NQO1 found in solid tumours to cause tumour-specific cell death. METHODS: We performed a 3+3 dose e...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Br J Cancer
Prif Awduron: Gerber, David E., Beg, M. Shaalan, Fattah, Farjana, Frankel, Arthur E., Fatunde, Oluwatomilade, Arriaga, Yull, Dowell, Jonathan E., Bisen, Ajit, Leff, Richard D., Meek, Claudia C., Putnam, William C., Kallem, Raja Reddy, Subramaniyan, Indhumathy, Dong, Ying, Bolluyt, Joyce, Sarode, Venetia, Luo, Xin, Xie, Yang, Schwartz, Brian, Boothman, David A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6203852/
https://ncbi.nlm.nih.gov/pubmed/30318513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-018-0278-4
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