The NQO1 bioactivatable drug, β-lapachone, alters the redox state of NQO1+ pancreatic cancer cells, causing perturbation in central carbon metabolism

Many cancer treatments, such as those for managing recalcitrant tumors like pancreatic ductal adenocarcinoma, cause off-target toxicities in normal, healthy tissue, highlighting the need for more tumor-selective chemotherapies. β-Lapachone is bioactivated by NAD(P)H:quinone oxidoreductase 1 (NQO1)....

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Silvers, Molly A., Deja, Stanislaw, Singh, Naveen, Egnatchik, Robert A., Sudderth, Jessica, Luo, Xiuquan, Beg, Muhammad S., Burgess, Shawn C., DeBerardinis, Ralph J., Boothman, David A., Merritt, Matthew E.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2017
Teme:
Metabolism
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5672043/
https://ncbi.nlm.nih.gov/pubmed/28916726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.813923
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