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Common helical V1V2 conformations of HIV-1 Envelope expose the α4β7 binding site on intact virions
The α4β7 integrin is a non-essential HIV-1 adhesion receptor, bound by the gp120 V1V2 domain, facilitating rapid viral dissemination into gut-associated lymphoid tissues. Antibodies blocking this interaction early in infection can improve disease outcome, and V1V2-targeted antibodies were correlated...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6203816/ https://ncbi.nlm.nih.gov/pubmed/30367034 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06794-x |
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