A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs

Necroptosis is a regulated form of necrosis that depends on receptor-interacting protein kinase (RIPK)3 and mixed lineage kinase domain-like (MLKL). While danger-associated molecular pattern (DAMP)s are involved in various pathological conditions and released from dead cells, the underlying mechanis...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Murai, Shin, Yamaguchi, Yoshifumi, Shirasaki, Yoshitaka, Yamagishi, Mai, Shindo, Ryodai, Hildebrand, Joanne M., Miura, Ryosuke, Nakabayashi, Osamu, Totsuka, Mamoru, Tomida, Taichiro, Adachi-Akahane, Satomi, Uemura, Sotaro, Silke, John, Yagita, Hideo, Miura, Masayuki, Nakano, Hiroyasu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6203740/
https://ncbi.nlm.nih.gov/pubmed/30367066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06985-6
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