Interleukin 2 promotes hepatic regulatory T cell responses and protects from biliary fibrosis in murine sclerosing cholangitis

In the Mdr2−/− mouse model low phospholipid bile instigates biliary epithelial injury, sterile inflammation, and fibrosis, thereby recapitulating disease mechanisms implicated in biliary atresia (BA) and primary sclerosing cholangitis. We hypothesize that T-lymphocytes contribute to the biliary inju...

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Dades bibliogràfiques
Publicat a:Hepatology
Autors principals: Taylor, Amy E., Carey, Alexandra N., Kudira, Ramesh, Lages, Celine S., Shi, Tiffany, Lam, Simon, Karns, Rebekah, Simmons, Julia, Shanmukhappa, Kumar, Almanan, Maha, Chougnet, Claire A., Miethke, Alexander G.
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6203671/
https://ncbi.nlm.nih.gov/pubmed/29698570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.30061
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