Pharmacological inhibition of ASBT changes bile composition and blocks progression of sclerosing cholangitis in mdr2 knockout mice

Deficiency for mdr2, a canalicular phospholipid floppase, leads to excretion of low phospholipid “toxic” bile causing progressive cholestasis. We hypothesize that pharmacological inhibition of the ileal apical sodium-dependent bile acid transporter (ASBT) blocks progression of sclerosing cholangitis...

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Bibliografiska uppgifter
I publikationen:Hepatology
Huvudupphovsmän: Miethke, Alexander G, Zhang, Wujuan, Simmons, Julie, Taylor, Amy, Shi, Tiffany, Shanmukhappa, Shiva Kumar, Karns, Rebekah, White, Shana, Jegga, Anil G, Lages, Celine S, Nkinin, Stephenson, Keller, Bradley T, Setchell, Kenneth D. R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4713368/
https://ncbi.nlm.nih.gov/pubmed/26172874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.27973
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