Pharmacological inhibition of ASBT changes bile composition and blocks progression of sclerosing cholangitis in mdr2 knockout mice

Deficiency for mdr2, a canalicular phospholipid floppase, leads to excretion of low phospholipid “toxic” bile causing progressive cholestasis. We hypothesize that pharmacological inhibition of the ileal apical sodium-dependent bile acid transporter (ASBT) blocks progression of sclerosing cholangitis...

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Detalhes bibliográficos
Publicado no:Hepatology
Main Authors: Miethke, Alexander G, Zhang, Wujuan, Simmons, Julie, Taylor, Amy, Shi, Tiffany, Shanmukhappa, Shiva Kumar, Karns, Rebekah, White, Shana, Jegga, Anil G, Lages, Celine S, Nkinin, Stephenson, Keller, Bradley T, Setchell, Kenneth D. R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4713368/
https://ncbi.nlm.nih.gov/pubmed/26172874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.27973
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