Pharmacological inhibition of ASBT changes bile composition and blocks progression of sclerosing cholangitis in mdr2 knockout mice

Deficiency for mdr2, a canalicular phospholipid floppase, leads to excretion of low phospholipid “toxic” bile causing progressive cholestasis. We hypothesize that pharmacological inhibition of the ileal apical sodium-dependent bile acid transporter (ASBT) blocks progression of sclerosing cholangitis...

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Publicat a:Hepatology
Autors principals: Miethke, Alexander G, Zhang, Wujuan, Simmons, Julie, Taylor, Amy, Shi, Tiffany, Shanmukhappa, Shiva Kumar, Karns, Rebekah, White, Shana, Jegga, Anil G, Lages, Celine S, Nkinin, Stephenson, Keller, Bradley T, Setchell, Kenneth D. R.
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4713368/
https://ncbi.nlm.nih.gov/pubmed/26172874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.27973
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