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CRISPR-Cas9 off-targeting assessment with nucleic acid duplex energy parameters
BACKGROUND: Recent experimental efforts of CRISPR-Cas9 systems have shown that off-target binding and cleavage are a concern for the system and that this is highly dependent on the selected guide RNA (gRNA) design. Computational predictions of off-targets have been proposed as an attractive and more...
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| Publié dans: | Genome Biol |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
BioMed Central
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6203265/ https://ncbi.nlm.nih.gov/pubmed/30367669 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-018-1534-x |
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