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Establishment of a rapid and footprint-free protocol for differentiation of human embryonic stem cells into pancreatic endocrine cells with synthetic mRNAs encoding transcription factors

BACKGROUND: Transplantation of pancreatic β cells generated in vitro from pluripotent stem cells (hPSCs) such as embryonic stem cells (ESCs) or induced pluripotent stem cells (iPSCs) has been proposed as an alternative therapy for diabetes. Though many differentiation protocols have been developed f...

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書目詳細資料
發表在:	Stem Cell Res Ther
Main Authors:	Ida, Hideomi, Akiyama, Tomohiko, Ishiguro, Keiichiro, Goparaju, Sravan K., Nakatake, Yuhki, Chikazawa-Nohtomi, Nana, Sato, Saeko, Kimura, Hiromi, Yokoyama, Yukihiro, Nagino, Masato, Ko, Minoru S. H., Ko, Shigeru B. H.
格式:	Artigo
語言:	Inglês
出版:	BioMed Central 2018
主題:	Research
在線閱讀:	https://ncbi.nlm.nih.gov/pmc/articles/PMC6203190/ https://ncbi.nlm.nih.gov/pubmed/30359326 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-018-1038-3
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Establishment of a rapid and footprint-free protocol for differentiation of human embryonic stem cells into pancreatic endocrine cells with synthetic mRNAs encoding transcription factors

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