Induction of human pluripotent stem cells into kidney tissues by synthetic mRNAs encoding transcription factors

The derivation of kidney tissues from human pluripotent stem cells (hPSCs) and its application for replacement therapy in end-stage renal disease have been widely discussed. Here we report that consecutive transfections of two sets of synthetic mRNAs encoding transcription factors can induce rapid a...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Hiratsuka, Ken, Monkawa, Toshiaki, Akiyama, Tomohiko, Nakatake, Yuhki, Oda, Mayumi, Goparaju, Sravan Kumar, Kimura, Hiromi, Chikazawa-Nohtomi, Nana, Sato, Saeko, Ishiguro, Keiichiro, Yamaguchi, Shintaro, Suzuki, Sayuri, Morizane, Ryuji, Ko, Shigeru B. H., Itoh, Hiroshi, Ko, Minoru S. H.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6351687/
https://ncbi.nlm.nih.gov/pubmed/30696889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-37485-8
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