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Establishment of a rapid and footprint-free protocol for differentiation of human embryonic stem cells into pancreatic endocrine cells with synthetic mRNAs encoding transcription factors

BACKGROUND: Transplantation of pancreatic β cells generated in vitro from pluripotent stem cells (hPSCs) such as embryonic stem cells (ESCs) or induced pluripotent stem cells (iPSCs) has been proposed as an alternative therapy for diabetes. Though many differentiation protocols have been developed f...

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書誌詳細
出版年:Stem Cell Res Ther
主要な著者: Ida, Hideomi, Akiyama, Tomohiko, Ishiguro, Keiichiro, Goparaju, Sravan K., Nakatake, Yuhki, Chikazawa-Nohtomi, Nana, Sato, Saeko, Kimura, Hiromi, Yokoyama, Yukihiro, Nagino, Masato, Ko, Minoru S. H., Ko, Shigeru B. H.
フォーマット: Artigo
言語:Inglês
出版事項: BioMed Central 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6203190/
https://ncbi.nlm.nih.gov/pubmed/30359326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-018-1038-3
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