PBF509, an Adenosine A(2A) Receptor Antagonist With Efficacy in Rodent Models of Movement Disorders

Adenosine A(2A) receptor (A(2A)R) antagonists have emerged as complementary non-dopaminergic drugs to alleviate Parkinson’s disease (PD) symptomatology. Here, we characterize a novel non-xhantine non-furan A(2A)R antagonist, PBF509, as a potential pro-dopaminergic drug for PD management. First, PBF5...

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Bibliographische Detailangaben
Veröffentlicht in:Front Pharmacol
Hauptverfasser: Núñez, Fabiana, Taura, Jaume, Camacho, Juan, López-Cano, Marc, Fernández-Dueñas, Víctor, Castro, Naomi, Castro, Julio, Ciruela, Francisco
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6202948/
https://ncbi.nlm.nih.gov/pubmed/30405415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.01200
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