Reducing Glucokinase Activity Restores Endogenous Pulsatility and Enhances Insulin Secretion in Islets From db/db Mice

An early sign of islet failure in type 2 diabetes (T2D) is the loss of normal patterns of pulsatile insulin release. Disruptions in pulsatility are associated with a left shift in glucose sensing that can cause excessive insulin release in low glucose (relative hyperinsulinemia, a hallmark of early...

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Detalhes bibliográficos
Publicado no:Endocrinology
Main Authors: Jahan, Ishrat, Corbin, Kathryn L, Bogart, Avery M, Whitticar, Nicholas B, Waters, Christopher D, Schildmeyer, Cara, Vann, Nicholas W, West, Hannah L, Law, Nathan C, Wiseman, Jeffrey S, Nunemaker, Craig S
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6202857/
https://ncbi.nlm.nih.gov/pubmed/30239634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2018-00589
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