Evidence for persistence of the SHIV reservoir early after MHC haploidentical hematopoietic stem cell transplantation

Allogeneic transplantation (allo-HCT) has led to the cure of HIV in one individual, raising the question of whether transplantation can eradicate the HIV reservoir. To test this, we here present a model of allo-HCT in SHIV-infected, cART-suppressed nonhuman primates. We infect rhesus macaques with S...

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Izdano u:Nat Commun
Glavni autori: Colonna, Lucrezia, Peterson, Christopher W., Schell, John B., Carlson, Judith M., Tkachev, Victor, Brown, Melanie, Yu, Alison, Reddy, Sowmya, Obenza, Willi M., Nelson, Veronica, Polacino, Patricia S., Mack, Heather, Hu, Shiu-Lok, Zeleski, Katie, Hoffman, Michelle, Olvera, Joe, Furlan, Scott N., Zheng, Hengqi, Taraseviciute, Agne, Hunt, Daniel J., Betz, Kayla, Lane, Jennifer F., Vogel, Keith, Hotchkiss, Charlotte E., Moats, Cassie, Baldessari, Audrey, Murnane, Robert D., English, Christopher, Astley, Cliff A., Wangari, Solomon, Agricola, Brian, Ahrens, Joel, Iwayama, Naoto, May, Andrew, Stensland, Laurence, Huang, Meei-Li W., Jerome, Keith R., Kiem, Hans-Peter, Kean, Leslie S.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2018
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6202377/
https://ncbi.nlm.nih.gov/pubmed/30361514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06736-7
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