Repression of Mcl-1 expression by the CDC7/CDK9 inhibitor PHA-767491 overcomes bone marrow stroma-mediated drug resistance in AML

Acute myeloid leukaemia (AML) is an aggressive cancer with 50–75% of patients relapsing even after successful chemotherapy. The role of the bone marrow microenvironment (BMM) in protecting AML cells from chemotherapeutics and causing consequent relapse is increasingly recognised. However the role th...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: O’ Reilly, Eimear, Dhami, Sukhraj Pal S., Baev, Denis V., Ortutay, Csaba, Halpin-McCormick, Anna, Morrell, Ruth, Santocanale, Corrado, Samali, Afshin, Quinn, John, O’Dwyer, Michael E, Szegezdi, Eva
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6202320/
https://ncbi.nlm.nih.gov/pubmed/30361682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-33982-y
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados