Mechanosensitive Gene Regulation by Myocardin-Related Transcription Factors is Required for Cardiomyocyte Integrity in Load-Induced Ventricular Hypertrophy

BACKGROUND: Hypertrophic cardiomyocyte (CM) growth and dysfunction accompanies various forms of heart disease. The mechanisms responsible for transcriptional changes that impact cardiac physiology and the transition to heart failure (HF) are not well understood. The intercalated disc (ID) is a speci...

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Udgivet i:Circulation
Main Authors: Trembley, Michael A., Quijada, Pearl, Agullo-Pascual, Esperanza, Tylock, Kevin M., Colpan, Mert, Dirkx, Ronald A., Myers, Jason R., Mickelsen, Deanne M., de Mesy Bentley, Karen, Rothenberg, Eli, Moravec, Christine S., Alexis, Jeffrey D., Gregorio, Carol C., Dirksen, Robert T., Delmar, Mario, Small, Eric M.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6202206/
https://ncbi.nlm.nih.gov/pubmed/29716942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.117.031788
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