Genome-wide association analysis identifies SNPs predictive of in vitro leukemic cell sensitivity to cytarabine in pediatric AML

Cytarabine has been an integral part of acute myeloid leukemia (AML) chemotherapy for over four decades. However, development of resistance and high rates of relapse is a significant impediment in successfully treating AML. We performed a genome-wide association analysis (GWAS) and identified 113 (8...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Bargal, Salma A., Rafiee, Roya, Crews, Kristine R., Wu, Huiyun, Cao, Xueyuan, Rubnitz, Jeffrey E., Ribeiro, Raul C., Downing, James R., Pounds, Stanley B., Lamba, Jatinder K.
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2018
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6201857/
https://ncbi.nlm.nih.gov/pubmed/30405880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26163
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