Genome-wide association analysis identifies SNPs predictive of in vitro leukemic cell sensitivity to cytarabine in pediatric AML

Cytarabine has been an integral part of acute myeloid leukemia (AML) chemotherapy for over four decades. However, development of resistance and high rates of relapse is a significant impediment in successfully treating AML. We performed a genome-wide association analysis (GWAS) and identified 113 (8...

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Pubblicato in:Oncotarget
Autori principali: Bargal, Salma A., Rafiee, Roya, Crews, Kristine R., Wu, Huiyun, Cao, Xueyuan, Rubnitz, Jeffrey E., Ribeiro, Raul C., Downing, James R., Pounds, Stanley B., Lamba, Jatinder K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2018
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6201857/
https://ncbi.nlm.nih.gov/pubmed/30405880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26163
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