VPO1 Modulates Vascular Smooth Muscle Cell Phenotypic Switch by Activating Extracellular Signal‐regulated Kinase 1/2 (ERK 1/2) in Abdominal Aortic Aneurysms

BACKGROUND: Hydrogen peroxide (H(2)O(2)) is a critical molecular signal in the development of abdominal aortic aneurysm (AAA) formation. Vascular peroxidase 1 (VPO1) catalyzes the production of hypochlorous acid (HOCl) from H(2)O(2) and significantly enhances oxidative stress. The switch from a cont...

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Detalhes bibliográficos
Publicado no:J Am Heart Assoc
Main Authors: Peng, Huihui, Zhang, Kai, Liu, Zhaoya, Xu, Qian, You, Baiyang, Li, Chan, Cao, Jing, Zhou, Honghua, Li, Xiaohui, Chen, Jia, Cheng, Guangjie, Shi, Ruizheng, Zhang, Guogang
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6201418/
https://ncbi.nlm.nih.gov/pubmed/30371171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.118.010069
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