Disrupting Gram-Negative Bacterial Outer Membrane Biosynthesis through Inhibition of the Lipopolysaccharide Transporter MsbA

There is a critical need for new antibacterial strategies to counter the growing problem of antibiotic resistance. In Gram-negative bacteria, the outer membrane (OM) provides a protective barrier against antibiotics and other environmental insults. The outer leaflet of the outer membrane is primaril...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Alexander, Mary Kate, Miu, Anh, Oh, Angela, Reichelt, Mike, Ho, Hoangdung, Chalouni, Cecile, Labadie, Sharada, Wang, Lan, Liang, Jun, Nickerson, Nicholas N., Hu, Huiyong, Yu, Lan, Du, Miaofen, Yan, Donghong, Park, Summer, Kim, Janice, Xu, Min, Sellers, Benjamin D., Purkey, Hans E., Skelton, Nicholas J., Koehler, Michael F. T., Payandeh, Jian, Verma, Vishal, Xu, Yiming, Koth, Christopher M., Nishiyama, Mireille
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2018
Témata:
Experimental Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6201111/
https://ncbi.nlm.nih.gov/pubmed/30104274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01142-18
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