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Synthetic Ingenols Maximize Protein Kinase C-Induced HIV-1 Latency Reversal

Antiretroviral therapy (ART) does not cure HIV-1 infection due to the persistence of proviruses in long-lived resting T cells. Strategies targeting these latently infected cells will be necessary to eradicate HIV-1 in infected individuals. Protein kinase C (PKC) activation is an effective mechanism...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Spivak, Adam M., Nell, Racheal A., Petersen, Mark, Martins, Laura, Sebahar, Paul, Looper, Ryan E., Planelles, Vicente
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6201092/
https://ncbi.nlm.nih.gov/pubmed/30104276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01361-18
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