Janus kinase inhibition suppresses PKC-induced cytokine release without affecting HIV-1 latency reversal ex vivo

BACKGROUND: Despite the durable viral suppression afforded by antiretroviral therapy, HIV-1 eradication will require strategies to target latently infected cells that persist in infected individuals. Protein kinase C (PKC) activation is a promising strategy to reactivate latent proviruses and allow...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Retrovirology
Päätekijät: Spivak, Adam M., Larragoite, Erin T., Coletti, McKenna L., Macedo, Amanda B., Martins, Laura J., Bosque, Alberto, Planelles, Vicente
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BioMed Central 2016
Aiheet:
Research
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5175306/
https://ncbi.nlm.nih.gov/pubmed/27998278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-016-0319-0
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