In Vitro Antiviral Profile of Ruzasvir, a Potent and Pangenotype Inhibitor of Hepatitis C Virus NS5A

Inhibition of NS5A has emerged as an attractive strategy to intervene in hepatitis C virus (HCV) replication. Ruzasvir (formerly MK-8408) was developed as a novel NS5A inhibitor to improve upon the potency and barrier to resistance of early compounds. Ruzasvir inhibited HCV RNA replication with 50%...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Asante-Appiah, Ernest, Liu, Rong, Curry, Stephanie, McMonagle, Patricia, Agrawal, Sony, Carr, Donna, Rokosz, Laura, Lahser, Frederick, Bystol, Karin, Chase, Robert, Black, Stuart, Ferrari, Eric, Ingravallo, Paul, Tong, Ling, Yu, Wensheng, Kozlowski, Joseph
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2018
Schlagworte:
Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6201069/
https://ncbi.nlm.nih.gov/pubmed/30150466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01280-18
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