The NFκB subunit RELA is a master transcriptional regulator of the committed epithelial-mesenchymal transition in airway epithelial cells

The epithelial-mesenchymal transition (EMT) is a multistep dedifferentiation program important in tissue repair. Here, we examined the role of the transcriptional regulator NF-κB in EMT of primary human small airway epithelial cells (hSAECs). Surprisingly, transforming growth factor β (TGFβ) activat...

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Vydáno v:J Biol Chem
Hlavní autoři: Tian, Bing, Widen, Steven G., Yang, Jun, Wood, Thomas G., Kudlicki, Andrzej, Zhao, Yingxin, Brasier, Allan R.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2018
Témata:
Gene Regulation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6200927/
https://ncbi.nlm.nih.gov/pubmed/30166344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003662
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