Human factor H domains 6 and 7 fused to IgG1 Fc are immunotherapeutic against Neisseria gonorrhoeae

Novel therapeutics against multidrug-resistant Neisseria gonorrhoeae are urgently needed. Gonococcal lipooligosaccharide (LOS) often expresses lacto-N-neotetraose (LNnT), which becomes sialylated in vivo, enhancing factor H (FH) binding and contributing to the organism’s ability to resist killing by...

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Udgivet i:J Immunol
Main Authors: Shaughnessy, Jutamas, Lewis, Lisa A., Zheng, Bo, Carr, Caleb, Bass, Isaac, Gulati, Sunita, DeOliveira, Rosane B., Gose, Severin, Reed, George W., Botto, Marina, Rice, Peter A., Ram, Sanjay
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6200640/
https://ncbi.nlm.nih.gov/pubmed/30266769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1701666
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