Genome-wide analyses reveal the IRE1a-XBP1 pathway promotes T helper cell differentiation by resolving secretory stress and accelerating proliferation

BACKGROUND: The IRE1a-XBP1 pathway is a conserved adaptive mediator of the unfolded protein response. The pathway is indispensable for the development of secretory cells by facilitating protein folding and enhancing secretory capacity. In the immune system, it is known to function in dendritic cells...

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Vydáno v:Genome Med
Hlavní autoři: Pramanik, Jhuma, Chen, Xi, Kar, Gozde, Henriksson, Johan, Gomes, Tomás, Park, Jong-Eun, Natarajan, Kedar, Meyer, Kerstin B., Miao, Zhichao, McKenzie, Andrew N. J., Mahata, Bidesh, Teichmann, Sarah A.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2018
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6199730/
https://ncbi.nlm.nih.gov/pubmed/30355343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-018-0589-3
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