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Convergent Metabotropic Signaling Pathways Inhibit SK Channels to Promote Synaptic Plasticity in the Hippocampus

Hebbian synaptic plasticity at hippocampal Schaffer collateral synapses is tightly regulated by postsynaptic small conductance (SK) channels that restrict NMDA receptor activity. SK channels are themselves modulated by G-protein-coupled signaling pathways, but it is not clear under what conditions t...

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Pubblicato in:J Neurosci
Autori principali: Tigaret, Cezar M., Chamberlain, Sophie E.L., Sadowski, Joseph H.L.P., Hall, Jeremy, Ashby, Michael C., Mellor, Jack R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6199408/
https://ncbi.nlm.nih.gov/pubmed/30242046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1160-18.2018
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