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Allele-specific epigenome maps reveal sequence-dependent stochastic switching at regulatory loci
To assess the impact of genetic variation in regulatory loci on human health, we construct a high-resolution map of allelic imbalances in DNA methylation, histone marks, and gene transcription in 71 epigenomes from 36 distinct cell and tissue types from 13 donors. Deep whole-genome bisulfite sequenc...
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| Publicat a: | Science |
|---|---|
| Autors principals: | , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6198826/ https://ncbi.nlm.nih.gov/pubmed/30139913 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aar3146 |
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