Targeting histone methyltransferase G9a inhibits growth and Wnt signaling pathway by epigenetically regulating HP1α and APC2 gene expression in non-small cell lung cancer

BACKGROUND: Dysregulated histone methyltransferase G9a may represent a potential cancer therapeutic target. The roles of G9a in tumorigenesis and therapeutics are not well understood in non-small cell lung cancer (NSCLC). Here we investigated the impact of G9a on tumor growth and signaling pathways...

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Veröffentlicht in:Mol Cancer
Hauptverfasser: Zhang, Keqiang, Wang, Jinhui, Yang, Lu, Yuan, Yate-Ching, Tong, Tommy R., Wu, Jun, Yun, Xinwei, Bonner, Melissa, Pangeni, Rajendra, Liu, Zheng, Yuchi, Tiger, Kim, Jae Y., Raz, Dan J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2018
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6198520/
https://ncbi.nlm.nih.gov/pubmed/30348169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-018-0896-8
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