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Beyond the histone tale: HP1α deregulation in breast cancer epigenetics

Heterochromatin protein 1α (HP1α) encoded from the CBX5-gene is an evolutionary conserved protein that binds histone H3 di- or tri-methylated at position lysine 9 (H3K9me2/3), a hallmark for heterochromatin, and has an essential role in forming higher order chromatin structures. HP1α has diverse fun...

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Bibliografiske detaljer
Udgivet i:Cancer Biol Ther
Main Authors: Vad-Nielsen, Johan, Nielsen, Anders Lade
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622548/
https://ncbi.nlm.nih.gov/pubmed/25588111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2014.1001277
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