Genome editing of oncogenes with ZFNs and TALENs: caveats in nuclease design

BACKGROUND: Gene knockout technologies involving programmable nucleases have been used to create knockouts in several applications. Gene editing using Zinc-finger nucleases (ZFNs), Transcription activator like effectors (TALEs) and CRISPR/Cas systems has been used to create changes in the genome in...

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Bibliografiske detaljer
Udgivet i:Cancer Cell Int
Main Authors: Shankar, Sumitra, Sreekumar, Ahalya, Prasad, Deepti, Das, Ani V., Pillai, M. Radhakrishna
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2018
Fag:
Primary Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6198504/
https://ncbi.nlm.nih.gov/pubmed/30386178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12935-018-0666-0
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