Enhanced Tailored MicroRNA Sponge Activity of RNA Pol II-Transcribed TuD Hairpins Relative to Ectopically Expressed ciRS7-Derived circRNAs

As key regulators of gene expression, microRNAs (miRNAs) have emerged as targets in basic experimentation and therapy. Administration of DNA-encoded RNA molecules, targeting miRNAs through base pairing, is one viable strategy for inhibiting specific miRNAs. A naturally occurring circular RNA (circRN...

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Publicado en:Mol Ther Nucleic Acids
Main Authors: Hollensen, Anne Kruse, Andersen, Sofie, Hjorth, Karina, Bak, Rasmus O., Hansen, Thomas B., Kjems, Jørgen, Aagaard, Lars, Damgaard, Christian Kroun, Mikkelsen, Jacob Giehm
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Gene & Cell Therapy 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6198105/
https://ncbi.nlm.nih.gov/pubmed/30347350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2018.09.009
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