Discovery of a Novel Na(v)1.7 Inhibitor From Cyriopagopus albostriatus Venom With Potent Analgesic Efficacy

Spider venoms contain a vast array of bioactive peptides targeting ion channels. A large number of peptides have high potency and selectivity toward sodium channels. Na(v)1.7 contributes to action potential generation and propagation and participates in pain signaling pathway. In this study, we desc...

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Bibliografske podrobnosti
izdano v:Front Pharmacol
Main Authors: Zhang, Yunxiao, Peng, Dezheng, Huang, Biao, Yang, Qiuchu, Zhang, Qingfeng, Chen, Minzhi, Rong, Mingqiang, Liu, Zhonghua
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2018
Teme:
Pharmacology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6198068/
https://ncbi.nlm.nih.gov/pubmed/30386239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.01158
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