Engineering Gain-of-Function Analogues of the Spider Venom Peptide HNTX-I, A Potent Blocker of the hNa(V)1.7 Sodium Channel

Pain is a medical condition that interferes with normal human life and work and reduces human well-being worldwide. Human voltage-gated sodium channel NaV1.7 (hNaV1.7) is a compelling target that plays a key role in human pain signaling. The 33-residue peptide µ-TRTX-Hhn2b (HNTX-I), a member of Na(V...

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Detalhes bibliográficos
Publicado no:Toxins (Basel)
Main Authors: Zhang, Yunxiao, Yang, Qiuchu, Zhang, Qingfeng, Peng, Dezheng, Chen, Minzhi, Liang, Songping, Zhou, Xi, Liu, Zhonghua
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6162447/
https://ncbi.nlm.nih.gov/pubmed/30181499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins10090358
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