Modeling effects of voltage dependent properties of the cardiac muscarinic receptor on human sinus node function

The cardiac muscarinic receptor (M2R) regulates heart rate, in part, by modulating the acetylcholine (ACh) activated K(+) current I(K,ACh) through dissociation of G-proteins, that in turn activate K(ACh) channels. Recently, M2Rs were noted to exhibit intrinsic voltage sensitivity, i.e. their affinit...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:PLoS Comput Biol
Main Authors: Moss, Robin, Sachse, Frank B., Moreno-Galindo, Eloy G., Navarro-Polanco, Ricardo A., Tristani-Firouzi, Martin, Seemann, Gunnar
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2018
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6197694/
https://ncbi.nlm.nih.gov/pubmed/30303952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1006438
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