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Isoform-specific activities of the regulatory subunits of phosphatidylinositol 3-kinases – potentially novel therapeutic targets

INTRODUCTION –: The main regulatory subunits of Class IA phosphatidylinositol 3-kinase (PI3K), p85α and p85β, initiate diverse cellular activities independent of binding to the catalytic subunit p110. Several of these signaling processes directly or indirectly contribute to a regulation of PI3K and...

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Détails bibliographiques
Publié dans:Expert Opin Ther Targets
Auteurs principaux: Ito, Yoshihiro, Hart, Jonathan R., Vogt, Peter K.
Format: Artigo
Langue:Inglês
Publié: 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6197473/
https://ncbi.nlm.nih.gov/pubmed/30205700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14728222.2018.1522302
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