Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1

The tumor suppressor and deubiquitinase (DUB) BAP1 and its Drosophila ortholog Calypso assemble DUB complexes with the transcription regulators Additional sex combs-like (ASXL1, ASXL2, ASXL3) and Asx respectively. ASXLs and Asx use their DEUBiquitinase ADaptor (DEUBAD) domain to stimulate BAP1/Calyp...

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Udgivet i:Nat Commun
Main Authors: Daou, Salima, Barbour, Haithem, Ahmed, Oumaima, Masclef, Louis, Baril, Caroline, Sen Nkwe, Nadine, Tchelougou, Daméhan, Uriarte, Maxime, Bonneil, Eric, Ceccarelli, Derek, Mashtalir, Nazar, Tanji, Mika, Masson, Jean-Yves, Thibault, Pierre, Sicheri, Frank, Yang, Haining, Carbone, Michele, Therrien, Marc, Affar, El Bachir
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6197237/
https://ncbi.nlm.nih.gov/pubmed/30349006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06854-2
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