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Computational analysis of ligand–receptor interactions in wild-type and mutant erythropoietin complexes
BACKGROUND: Erythropoietin (EPO), a pleiotropic cytokine, binds to its receptor (EPOR) in bone marrow, activating a signaling cascade that results in red blood cell proliferation. A recently discovered naturally occurring EPO mutation (R150Q) at active site 1 (AS1) of the protein was shown to attenu...
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| Publicado no: | Adv Appl Bioinform Chem |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Dove Medical Press
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6197206/ https://ncbi.nlm.nih.gov/pubmed/30410371 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/AABC.S177206 |
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