APP promotes osteoblast survival and bone formation by regulating mitochondrial function and preventing oxidative stress

Amyloid precursor protein (APP) is ubiquitously expressed in various types of cells including bone cells. Mutations in App gene result in early-onset Alzheimer’s disease (AD). However, little is known about its physiological function in bone homeostasis. Here, we provide evidence for APP’s role in p...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Pan, Jin-Xiu, Tang, Fulei, Xiong, Fei, Xiong, Lei, Zeng, Peng, Wang, Bo, Zhao, Kai, Guo, Haohan, Shun, Cui, Xia, Wen-Fang, Mei, Lin, Xiong, Wen-Cheng
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6197195/
https://ncbi.nlm.nih.gov/pubmed/30349052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-1123-7
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