Retinoic acid signaling balances adult distal lung epithelial progenitor cell growth and differentiation

BACKGROUND: Despite compelling data describing pro-regenerative effects of all-trans retinoic acid (ATRA) in pre-clinical models of chronic obstructive pulmonary disease (COPD), clinical trials using retinoids for emphysema patients have failed. Crucial information about the specific role of RA sign...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Ng-Blichfeldt, John-Poul, Schrik, Anneke, Kortekaas, Rosa K., Noordhoek, Jacobien A., Heijink, Irene H., Hiemstra, Pieter S., Stolk, Jan, Königshoff, Melanie, Gosens, Reinoud
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
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Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6197151/
https://ncbi.nlm.nih.gov/pubmed/30236449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.09.002
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