The structural organization of substrate loading in iterative polyketide synthases

Polyketide synthases (PKSs) are microbial multienzymes for the biosynthesis of biologically potent secondary metabolites. Polyketide production is initiated by the loading of a starter unit onto an integral acyl carrier protein (ACP) and its subsequent transfer to the ketosynthase (KS). Initial subs...

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Udgivet i:Nat Chem Biol
Main Authors: Herbst, Dominik A., Huitt-Roehl, Callie R., Jakob, Roman P., Kravetz, Jacob M., Storm, Philip A., Alley, Jamie R., Townsend, Craig A., Maier, Timm
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6196715/
https://ncbi.nlm.nih.gov/pubmed/29610486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-018-0026-3
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