Genetic fine mapping of systemic lupus erythematosus MHC associations in Europeans and African Americans

Genetic variation within the major histocompatibility complex (MHC) contributes substantial risk for systemic lupus erythematosus, but high gene density, extreme polymorphism and extensive linkage disequilibrium (LD) have made fine mapping challenging. To address the problem, we compared two associa...

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Vydáno v:Hum Mol Genet
Hlavní autoři: Hanscombe, Ken B, Morris, David L, Noble, Janelle A, Dilthey, Alexander T, Tombleson, Philip, Kaufman, Kenneth M, Comeau, Mary, Langefeld, Carl D, Alarcon-Riquelme, Marta E, Gaffney, Patrick M, Jacob, Chaim O, Sivils, Kathy L, Tsao, Betty P, Alarcon, Graciela S, Brown, Elizabeth E, Croker, Jennifer, Edberg, Jeff, Gilkeson, Gary, James, Judith A, Kamen, Diane L, Kelly, Jennifer A, McCune, Joseph, Merrill, Joan T, Petri, Michelle, Ramsey-Goldman, Rosalind, Reveille, John D, Salmon, Jane E, Scofield, Hal, Utset, Tammy, Wallace, Daniel J, Weisman, Michael H, Kimberly, Robert P, Harley, John B, Lewis, Cathryn M, Criswell, Lindsey A, Vyse, Timothy J
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
Témata:
Association Studies Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6196648/
https://ncbi.nlm.nih.gov/pubmed/30085094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddy280
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