Copper inhibits peptidoglycan LD-transpeptidases suppressing β-lactam resistance due to bypass of penicillin-binding proteins

The peptidoglycan (PG) layer stabilizes the bacterial cell envelope to maintain the integrity and shape of the cell. Penicillin-binding proteins (PBPs) synthesize essential 4–3 cross-links in PG and are inhibited by β-lactam antibiotics. Some clinical isolates and laboratory strains of Enterococcus...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Peters, Katharina, Pazos, Manuel, Edoo, Zainab, Hugonnet, Jean-Emmanuel, Martorana, Alessandra M., Polissi, Alessandra, VanNieuwenhze, Michael S., Arthur, Michel, Vollmer, Waldemar
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2018
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6196517/
https://ncbi.nlm.nih.gov/pubmed/30275297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1809285115
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