Factors essential for L,D-transpeptidase-mediated peptidoglycan cross-linking and β-lactam resistance in Escherichia coli

The target of β-lactam antibiotics is the D,D-transpeptidase activity of penicillin-binding proteins (PBPs) for synthesis of 4→3 cross-links in the peptidoglycan of bacterial cell walls. Unusual 3→3 cross-links formed by L,D-transpeptidases were first detected in Escherichia coli more than four deca...

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Dettagli Bibliografici
Pubblicato in:eLife
Autori principali: Hugonnet, Jean-Emmanuel, Mengin-Lecreulx, Dominique, Monton, Alejandro, den Blaauwen, Tanneke, Carbonnelle, Etienne, Veckerlé, Carole, Brun, Yves, V., van Nieuwenhze, Michael, Bouchier, Christiane, Tu, Kuyek, Rice, Louis B, Arthur, Michel
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2016
Soggetti:
Microbiology and Infectious Disease
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5089857/
https://ncbi.nlm.nih.gov/pubmed/27767957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.19469
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